Preterm labor and fetal distress, intracranial. Maternal Risk: Postpartum bleeding caused by Vitamin K deficiencyįetal Risk: Stillbirth, risk increases towards term, but does not correlate with maternal symptoms or transaminase levels. Liver autoantibodies (for pre-existing liver disease, anti-smooth muscle antibody/chronic active hepatitis, antimitochondrial antibodies/primary/ biliary cirrhosis). Hepatitis, primary biliary cirrhosis, sclerosing cholangitis, gall stones.Įventually rule out by liver ultrasound, viral serology (for hepatitis A, B and C, EBV, CMV) Increased (10 to 100 folds) serum bile acid (but normally nok available). Raised gamma-glutamyl transpeptidase (yGT) (about 20 % of cases) Mild elevated transaminase < 3 fold very seldom up to 10 fold. Pruritus without rash, worse at palms of hands and soles of feet. Starts in the second half of pregnancy usually in the third trimester. The incidence is higher in Scandinavia, Chile and China, Obstetric cholestasis (Pruritus gravidarum) If present, during several pregnancies it is associated with increased risks of cholelithiasis. The pathophysiology is considered to be a mind cholestasis. In one study on 693 women no complication were seen with bile acid level < 40 micromol/L. Liver enzymes often slightly elevated and the patients can be mildly icteric. Intrahepatic cholestadid of pregnancy (Pruritus gravidarum) (also called obstetric cholestasis)īetween 0.02-2.4% of pregnancies develop itching in the third trimester beginning on the abdomen, but can become widespread. They are of course most effective for urticarial pruritus. Therapy will be according to an eventual diagnosis.Īnti-histamines can be tried and do not increase the risk for the child.
#Permethrin cream pregnancy skin#
An underlying skin disease should be considered including eczema, urticaria, psoriasis, scabies, drug eruptions. Itching - or pruritus - affects up to 1/5 of pregnant women. However, they are not absorbed and will likely not influence the pregnancy. Tacrolimus and pimecrolimus (topical calcineurin-inhibitors used for treatment of atopic eczema) should not be used as no experience exists. Topical steroid therapy during pregnancy for eczema, psoriasis or other diseases does not give any risks for the child even though small amounts of the steroids are absorbed. Pityrosporum folliculitis on trunk ketoconazole shampooĭermatophytosis - treat with topical therapy only - econozale, ketoconazole, lamisilĪtopic eczema has a variable course during pregnancy, but the mother often fights eczema of the nipples during breast-feeding and irritant hand eczema postpartum due to increased skin irritation. Herpes simplextopical or systemic treatment Increase of skin infections because of reduction in cell-mediated immunityĬandidiasis clotrimazole or miconazole in a cream basesĬondyloma acuminatanever treat with podofyllin physical removal Gingivial oedema and redness (in up to 80% of pregnant women) Įdema of face, hands and feet - most pronounced in the morning Varicose veins of legs and risk of haemorrhoids. Topical low-potency steroids and/or calamine lotion. Increased tendency of sweating with miliaria rubra on trunk. Topical treatment like adapalene gel, or benzoyl peroxide 5 - 10% cream. Increased hair growth with ensuing postpartum hair loss. Use sun blockers and hydroquinol crème, 2 or 4%, for bleaching.
irregular hyperpigmentation in forehead and temples of face. Increased size and number of melanocytic nevi.Ĭhloasma i.e. Increased pigmentation especially in dark-haired women. Physiological skin changes related to pregnancy Physiological skin changes related to pregnancy.Pruritic urticarial papules and plagues of pregnancy (PUPPP).Herpes gestationis (or pemphigoid gestationis).Obstetric cholestasis (Pruritus gravidarum).Pruritus gravidarum (also called obstetric cholestasis).Main and Danish guidelines by the web master
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